22)What is Multidrug-resistant tuberculosis, and how did Mycobacterium tuberculosis become resistant to antibiotics?

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22)What is Multidrug-resistant tuberculosis, and how did Mycobacterium tuberculosis become resistant to antibiotics?

answer : 

The bacteria that cause tuberculosis (TB) can develop resistance to the antimicrobial drugs used to cure the disease. Multidrug-resistant TB (MDR-TB) is TB that does not respond to at least isoniazid and rifampicin, the 2 most powerful anti-TB drugs.

Drug resistance in TB remains a man-made phenomenon. It emerges as a result of spontaneous gene mutations in M. tuberculosis that render the bacteria resistant to the most commonly used anti-TB drugs. Among the reasons for this, the non-compliance with the treatment regimens is signaled as the first cause.


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